The impact of common and rare genetic variants on bradyarrhythmia development

Affiliations

• ¹ Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
• ² Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ³ VA Boston Healthcare System, Boston, MA, USA.
• ⁴ Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
• ⁵ The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ⁶ Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
• ⁷ Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA.
• ⁸ Gene Regulation Observatory, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ⁹ Cardiovascular Medicine Division, Brigham and Women's Hospital, Boston, MA, USA.
• ¹⁰ VA Atlanta Healthcare System, Decatur, GA, USA.
• ¹¹ Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
• ¹² Heart Institute, Geisinger, Danville, PA, USA.
• ¹³ Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
• ¹⁴ McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ¹⁵ Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
• ¹⁶ The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University, Gothenburg, Sweden.
• ¹⁷ Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
• ¹⁸ Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
• ¹⁹ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ²⁰ Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
• ²¹ Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
• ²² Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.
• ²³ Division of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
• ²⁴ Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ²⁵ Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada.
• ²⁶ Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, WI, USA.
• ²⁷ Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA, USA.
• ²⁸ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
• ²⁹ Epidemiological Cardiology Research Center, Section on Cardiovascular Medicine, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
• ³⁰ Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
• ³¹ Department of Cardiology, Clinical Sciences, Lund University and Skane University Hospital, Lund, Sweden.
• ³² Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
• ³³ Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• ³⁴ Section of Cardiac Electrophysiology, Western University, London, Ontario, Canada.
• ³⁵ Department of Medicine, University of Utah, Salt Lake City, UT, USA.
• ³⁶ Department of Economics, Leiden Law School, Leiden University, Leiden, The Netherlands.
• ³⁷ Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Center, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
• ³⁸ Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
• ³⁹ Harvard Medical School, Boston, MA, USA.
• ⁴⁰ Brigham and Women's Hospital, Boston, MA, USA.
• ⁴¹ Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
• ⁴² Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ⁴³ Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
• ⁴⁴ Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.
• ⁴⁵ Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
• ⁴⁶ Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
• ⁴⁷ NHLBI and BU's Framingham Heart Study, Framingham, MA, USA.
• ⁴⁸ Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
• ⁴⁹ Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
• ⁵⁰ Vanderbilt University Medical Center, Nashville, TN, USA.
• ⁵¹ Department of Genetics and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁵² Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
• ⁵³ The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ⁵⁴ Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
• ⁵⁵ Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
• ⁵⁶ Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, MA, USA. [email protected].