Demographic and clinical factors associated with functional changes in Long-Covid

Many people experience symptoms months or years following COVID-19 infection. The impact of these symptoms on daily functioning and factors associated with functional decline are not well understood. This study aimed to describe functional changes among persons with Long-Covid and explore associated sociodemographic and clinical factors. 2764 adults who tested positive for COVID-19 were recruited at >12 weeks after diagnosis. Participants responded to an electronic survey [Newcastle Post-COVID Syndrome Questionnaire (symptoms); COVID-19 Yorkshire Rehabilitation Screen (activities; perceived global health, mobility, personal care, daily activities)]. 37.8% were classified as having Long-Covid based on the positive response to "Are you still troubled by symptoms?". The majority of them reported a decline in global health, mobility, and participation in daily activities. Common changes in function included fatigue, breathlessness upon climbing stairs and when dressing, decline in participation in usual activities, anxiety, pain/discomfort, and reduced concentration. Having COVID-19 > 1 year prior was associated with change in perceived global health (OR = 1.5). Being infected >12 months prior (OR = 1.5), hospitalized for COVID-19 (OR = 2.2-2.4), >1 chronic comorbid conditions (OR = 1.6), and obesity (OR = 1.6) were associated with functional decline. Many of those infected with COVID-19 experience long-lasting symptoms impacting daily functioning. Multidisciplinary medical and rehabilitation services are needed to help improve recovery and maximize functioning.