Visible-light-induced aerobic oxidative cyclization of nitroarenes with triethylamine using an organophotocatalyst

Org Biomol Chem. 2025 Jan 3. doi: 10.1039/d4ob01714e. Online ahead of print.

Abstract

Isoxazolidines are structurally important scaffolds in many natural products and bioactive compounds. Herein, we report a novel synthetic method for isoxazolidine derivatives through visible-light-induced photoredox cascade cyclization of nitroarenes with triethylamine under aerobic conditions. The resultant 5-hydroxyl isoxazolidine compounds were generally obtained in moderate yields with a broad range of compatible functionalities.