The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study

Wei Fu; Junlong Zhao; GuoBin Chen; Linya Lyu; Yao Ding; Liang-Bi Xu

doi:10.1371/journal.pone.0295888

The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study

PLoS One. 2025 Jan 3;20(1):e0295888. doi: 10.1371/journal.pone.0295888. eCollection 2025.

Authors

Wei Fu¹, Junlong Zhao², GuoBin Chen¹, Linya Lyu¹, Yao Ding¹, Liang-Bi Xu³

Affiliations

¹ Department of Gastroenterology, 925th Hospital of PLA Joint Logistics Support Force, Guiyang, China.
² Department of Medical Genetics and Developmental Biology, State Key Laboratory of Cancer Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
³ Department of the Digestive Endoscopy, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Abstract

Background: The Triglyceride-glucose (TyG) index is a marker for insulin resistance and metabolic syndrome, while Helicobacter pylori is linked to gastrointestinal diseases and may affect metabolic risks. This study examined the association between the TyG index and H. pylori infection in adults.

Methods: Data from 3797 participants in the NHANES 1999-2000 cycle were analyzed. The relationship between the TyG index and H. pylori infection was assessed using multivariate logistic regression and a two-piecewise logistic model to explore non-linear effects. Subgroup analyses were conducted based on age, sex, glucose levels, BMI, and CKD.

Results: A linear association between the TyG index and H. pylori infection was found. Subgroup analyses revealed significant interactions with a few variables.

Conclusions: This study indicates a linear relationship between the TyG index and H. pylori infection, suggesting metabolic influences on H. pylori infection and potential for targeted interventions in at-risk groups.

Copyright: © 2025 Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

MeSH terms

Adult
Aged
Blood Glucose* / analysis
Blood Glucose* / metabolism
Cross-Sectional Studies
Female
Helicobacter Infections* / blood
Helicobacter Infections* / complications
Helicobacter Infections* / epidemiology
Helicobacter pylori*
Humans
Male
Middle Aged
Nutrition Surveys
Retrospective Studies
Triglycerides* / blood
United States / epidemiology

Substances

Triglycerides
Blood Glucose

Grants and funding

This work was supported by National Natural Science Foundation of China (Grant No. 82373270),Guizhou Provincial Department of Science and Technology Natural Science Foundation (No Foundation-ZK[2022]), Guizhou Provincial Health Commission Science and Technology Fund (No.gzwkj2023-135), and Science Foundation of 925th hospital (No. 2023[3]), (No. 2022[3/4]). As the principal investigator, Wei Fu, supported by various funding sources, Junlong Zhao, funded by the National Natural Science Foundation of China (Grant No. 82373270), and Liang-Bi Xu, funded by the Guizhou Provincial Department of Science and Technology Natural Science Foundation (No Foundation-ZK[2022]) were involved in the research. Wei Fu was responsible for the conceptualization and design, data curation, and drafting of the original manuscript, while Junlong Zhao played a key role in methodology, formal analysis, and investigation.