Case Report: osteonecrosis of the maxilla and mandible related to trastuzumab, docetaxel and carboplatin

Hélder Antônio Rabelo Pontes; Carina Barros do Amaral; Esther Castro de Menezes; Ana Luisa Sirotheau Corrêa Pontes; Igor Mesquita Lameira; Alessio Silva de Souza; Suelen Castro Lavareda Corrêa; Tatiana Ferreira Foscaldo; Flávia Sirotheau Correa Pontes

doi:10.1016/j.oooo.2024.12.003

Case Report: osteonecrosis of the maxilla and mandible related to trastuzumab, docetaxel and carboplatin

Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 Dec 9:S2212-4403(24)00937-4. doi: 10.1016/j.oooo.2024.12.003. Online ahead of print.

Authors

Hélder Antônio Rabelo Pontes¹, Carina Barros do Amaral², Esther Castro de Menezes², Ana Luisa Sirotheau Corrêa Pontes², Igor Mesquita Lameira³, Alessio Silva de Souza², Suelen Castro Lavareda Corrêa², Tatiana Ferreira Foscaldo⁴, Flávia Sirotheau Correa Pontes²

Affiliations

¹ Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Para, Belem, Para, Brazil; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
² Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Para, Belem, Para, Brazil.
³ Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Para, Belem, Para, Brazil. Electronic address: [email protected].
⁴ Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Para, Belem, Para, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

PMID: 39753430
DOI: 10.1016/j.oooo.2024.12.003

Abstract

We present a case of a patient with HER-2 positive breast cancer who developed extensive areas of osteonecrosis in the mandible and maxilla due to the combination of trastuzumab, carboplatin, and docetaxel. The pathogenesis is discussed based on the literature.

Publication types

Case Reports