A generic and dynamic measure of health-related quality of life across a variety of health and disease conditions: insights from healthy individuals and patients with a variety of diagnoses

BMC Res Notes. 2025 Jan 3;18(1):2. doi: 10.1186/s13104-024-07037-7.

Abstract

Objectives: Health-Significant Quality of Life Measure (Health-SigQOLM) provides a generic and dynamic assessment of Health-related quality of life (HRQOL). This study aims to assess the HRQOL among healthy and non-healthy participants with varying chronic diseases.

Results: Comparisons between healthy and non-healthy participants revealed statistically significant differences (p < 0.001) in the mean overall HRQOL score as well as across all its nine domains. Therefore, the Health-SigQOLM, along with its nine domains, is demonstrated to have adequate sensitivity in distinguishing between healthy and non-healthy study participants. This had supported the evidence that the Health-SigQOLM is a reliable and valid scale for measuring both generic and dynamic HRQOL.

Keywords: Health-related quality of life; Healthy; Patients.

MeSH terms

  • Adult
  • Aged
  • Chronic Disease / psychology
  • Female
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • Quality of Life* / psychology
  • Surveys and Questionnaires
  • Young Adult