Are impulsive compulsive behaviors associated with levodopa-induced dyskinesia? A Brazilian cross-sectional study

Purpose of this research: To study the association between ICBs and LIDs and to assess the predictors of ICBs in this sample.

Methods: We intentionally evaluated 90 Brazilian PD patients younger than 60 in one evaluation that included the application of Questionnaire for Impulsive Compulsive Disorders - Current Short (QUIP-CS), Barratt Impulsive Scale-11 (BIS-11), Beck Depression Inventory-II (BDI-II), Unified Parkinson's Disease Rating Scale parts III and IV, Unified Dyskinesia Rating Scale (UDysRS), and a cognitive assessment.

Results: ICB group had a longer PD duration (8.8 ± 5.2 y vs. 6.3 ± 3.3 y, p = 0.01), higher LEDDs (852.1 ± 381.8 mg vs.669.8 ± 404.4 mg, p = 0.03), higher BIS-11 scores (64.3 ± 12.7 vs. 58.6 ± 9.7, p = 0.01) and higher historical off-dystonia sub-scores (3.9 ± 5.0 vs. 2.0 ± 4.0, p = 0,05). LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk in both logistic models performed. MCI did not relate to ICBs.

Conclusion: In this study, LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk.