Toxic effects and mechanistic insights of cadmium telluride quantum dots on the homeostasis and regeneration in planarians

The widespread application of quantum dots (QDs) in recent years has raised concerns about potential environmental and human health risks. Although the toxicity of cadmium telluride quantum dots (CdTe QDs) has been partially studied, their effects on stem cells, tissue regeneration, neurodevelopment, and neurobehavioral toxicity remain unclear. This study aimed to investigate the combined toxic effects and mechanisms of CdTe QDs on planarians at the individual, tissue, cellular, and molecular levels. The results showed that exposure to CdTe QDs led to tissue damage, abnormal motor behavior, delayed regeneration, morphological abnormalities, and reduced survival. Furthermore, CdTe QDs caused excessive stem cell proliferation, leading to defective differentiation of tissues such as the epidermis, cilia, protonephridia, muscle, and nerves. Neurotoxicity manifests as a reduction in the number of neurons and neurotransmitter imbalance. Further studies revealed that CdTe QDs induced cell death by promoting reactive oxygen species (ROS) accumulation, triggering oxidative stress and deoxyribonucleic acid (DNA) damage, which led to excessive mitochondrial fission and activation of the mitochondria-dependent apoptotic signaling pathway. Overall, the balance between stem cell proliferation, differentiation, and apoptosis was disrupted, ultimately leading to delayed regeneration and homeostatic imbalance. These findings offer new insights into the environmental risk assessment of QDs and provide valuable directions for further research on their toxic effects on human stem cells and regenerative processes.