After the maturity period, human bones will experience aging changes such as decreased bone mass, abnormal trabecular structure and increased bone fragility. In recent years, with the development of aging research, research on bone aging markers has increased. Primary osteoporosis, which is related to aging, also belongs to the category of bone aging. This article will review the knowledge related to aging, bone aging markers and osteoporosis to explain the interrelationships between them, and combine some research progress to propose to learn from the bone aging markers research in the field of osteoporosis research. Combining bone aging markers and osteoporosis, the discussion around aging, bone aging, and osteoporosis will provide new ideas for further research on osteoporosis.
人体骨骼过了成熟期后，会随着年龄增加出现骨量减少、骨小梁结构异常、骨脆性增加等骨衰老改变。近些年，伴随着衰老研究发展，骨衰老标志物研究成果十分丰富。那么，作为与增龄相关的原发性骨质疏松症也是隶属于骨衰老的改变，所以，本文将梳理衰老、骨衰老标志物、骨质疏松症相关知识，分析相互关联、部分研究进展，提出在骨质疏松症研究范畴借鉴“骨衰老标志物”研究相应成果，将骨衰老标志物、骨质疏松症有机结合，围绕“衰老➝骨衰老➝骨质疏松症”长轴共同探讨相关问题，为骨质疏松症进一步研究提供新思路。.