New cytotoxic compounds from Viscum coloratum (Kom.) Nakai

Nat Prod Res. 2025 Jan 5:1-9. doi: 10.1080/14786419.2024.2448198. Online ahead of print.

Abstract

Twenty-one compounds were isolated and identified from the ethanol extract of Viscum coloratum (Kom.) Nakai, including two new compounds (1 and 3), a new artificial product (2) and eighteen known compounds (4-21). Compounds 4-9 and 11-20 were isolated from Santalaceae for the first time. In this paper, compounds' structures identified by NMR spectroscopy and compare their data with those in the literature. Meanwhile, all compounds were assessed for cytotoxic activity against HepG2 cells, revealing that compound 1 exhibited significant cytotoxicity with IC50 value 6.70 ± 2.12 μM.

Keywords: HepG2; Viscum coloratum (Kom.) nakai; diarylheptanoids; solanaceae; terpenes.