Intraventricular ganglioneuroblastoma: an uncommon location for a rare tumour in a young adult with review of literature

Int Cancer Conf J. 2024 Sep 18;14(1):12-16. doi: 10.1007/s13691-024-00726-x. eCollection 2025 Jan.

Abstract

Ganglioneuroblastoma (GNB) is a rare tumour of neuroectodermal origin consisting of a varying proportion of neuroblasts and ganglion cells. GNB arises from sympathoadrenal tissue usually affecting young children. Very few cases of brain GNB have been reported in the literature. To the best of our knowledge, this is the first-ever reported case of GNB at an intraventricular location in young adults. Because of the rarity of the neoplasm, it might be confused with other tumours of intraventricular location both in radiology and histopathology. We report a very rare case, which was surgically operated on and sent for a frozen section followed by a routine report. The final diagnosis was made by Immunohistochemistry (IHC) study. The patient was treated with further radiotherapy.

Keywords: Embryonal tumours; Foramen of Monro; Ganglioneuroblastoma; Intraventricular mass; Radiotherapy; Synaptophysin; WHO grading.