Putative epicenters identified by transcriptome-neuromorphic interactions in attention-deficit/hyperactivity disorder biotypes

Qin Tang; Jinzhong Peng; Yilu Li; Lin Liu; Pan Wang; Huafu Chen; Bharat B Biswal

doi:10.1016/j.pnpbp.2025.111247

Putative epicenters identified by transcriptome-neuromorphic interactions in attention-deficit/hyperactivity disorder biotypes

Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 4:111247. doi: 10.1016/j.pnpbp.2025.111247. Online ahead of print.

Authors

Qin Tang¹, Jinzhong Peng¹, Yilu Li¹, Lin Liu¹, Pan Wang², Huafu Chen³, Bharat B Biswal⁴

Affiliations

¹ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
² The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: [email protected].
³ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: [email protected].
⁴ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Department of Biomedical Engineering, New Jersey Institute of Technology, 11, Newark, NJ, 07102, USA. Electronic address: [email protected].

PMID: 39761817
DOI: 10.1016/j.pnpbp.2025.111247

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a heterogenous behavioral disorder with inattention, hyperactivity and impulsivity symptoms, indicating the important implication of identifying biotypes and its epicenters in understanding disease's pathogenesis. The study investigated the neuromorphic heterogeneity relating to transcriptional similarity architecture in ADHD, and further analyzed the epicenters of network-spreading in each ADHD biotype and their correlations with clinical characteristics. Individuals with ADHD could be identified into two discriminative biotypes that exhibited distinct neuromorphic aberrances. As increased regional cortical thickness deviation in ADHD, the first component of partial least squares (PLS1) positively weighted genes were over-expressed, whereas PLS1 negatively weighted genes were under-expressed as its reduction. Both ADHD biotypes exhibited distinct disease epicenters that distributed in cognitive control and attention networks with significantly heterogeneous characteristics, holding promise for advancing our understanding, and ultimately the treatment, of ADHD. Overall, our findings identified two discriminative biotypes and its epicenters in ADHD, promoting the understanding of underlying transcriptome-neuroimaging relationships.

Keywords: Attention-deficit hyperactivity disorder; Biotypes; Epicenters; Neuromorphic aberrances; Transcriptional similarity architecture.