Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs inhibitors

Bahaa Ibrahim Saeed; Abhinav Kumar; Enwa Felix Oghenemaro; Layla A Almutairi; Rekha M M; Rohit Kumawat; Subasini Uthirapathy; Hanen Mahmod Hulail; Shilpa Sharma; M Ravi Kumar

doi:10.1016/j.yexcr.2025.114406

Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs inhibitors

Exp Cell Res. 2025 Jan 4:114406. doi: 10.1016/j.yexcr.2025.114406. Online ahead of print.

Authors

Affiliations

¹ Medical Laboratory Techniques department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq. Electronic address: [email protected].
² Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg 620002, Russia; Department of Mechanical Engineering, Karpagam Academy of Higher Education, Coimbatore, India. 641021; Centre for Energy and Environment, Karpagam Academy of Higher Education, Coimbatore, India. 641021. Electronic address: [email protected].
³ Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, PMB 1 Abraka, Delta State, Nigeria. Electronic address: [email protected].
⁴ Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: [email protected].
⁵ Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India. Electronic address: [email protected].
⁶ Department of Neurology, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India. Electronic address: [email protected].
⁷ Faculty of Pharmacy, Pharmacology Department, Tishk International University, Erbil, Kurdistan Region of Iraq. Electronic address: [email protected].
⁸ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq. Electronic address: [email protected].
⁹ Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali 140307, Punjab, India. Electronic address: [email protected].
¹⁰ Department of Basic Science & Humanities,Raghu Engineering College, Visakhapatnam, India. Electronic address: [email protected].

PMID: 39761840
DOI: 10.1016/j.yexcr.2025.114406

Abstract

Transcription takes place over a significant portion of the human genome. However, only a small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; the majority of transcripts, on the other hand, comprise a variety of RNA families with varying sizes and functions. A substantial portion of this diverse RNA universe consists of sequences longer than 200 bases, called the long non-coding RNA (lncRNA). The control of gene transcription, changes to DNA topology, nucleosome organization and structure, paraspeckle creation, and assistance for developing cellular organelles are only a few of the numerous tasks performed by lncRNA. The main focus of this study is on the function of lncRNA in controlling the levels and actions of cyclin-dependent kinase inhibitors (CDKIs). The enzymes required for the mitotic cycle's regulated progression are called cyclin-dependent kinases (CDKs). They have many degrees of regulation over their activities and interact with CDKIs as their crucial mechanisms. Interestingly, culminating evidence has clarified that lncRNAs are associated with several illnesses and use CDKI regulation to control cellular function. Nonetheless, despite the abundance of solid evidence in the literature, it still seems unlikely that lncRNA will have much of an impact on controlling cell proliferation or modulating CDKIs.

Keywords: CDKs; Cancer; Cell growth; Cyclins; LncRNA.

Publication types

Review