Alkaloids and lignans isolated from Alisma orientale exhibit anti-pulmonary fibrosis activities by modulating an apoptotic signaling pathway

Deng-Hui Zhu; Jing-Ke Zhang; Peng-Li Guo; Si-Qi Tao; Meng-Nan Zeng; Xiao-Ke Zheng; Wei-Sheng Feng

doi:10.1016/j.phytochem.2025.114382

Alkaloids and lignans isolated from Alisma orientale exhibit anti-pulmonary fibrosis activities by modulating an apoptotic signaling pathway

Phytochemistry. 2025 Jan 4:114382. doi: 10.1016/j.phytochem.2025.114382. Online ahead of print.

Authors

Deng-Hui Zhu¹, Jing-Ke Zhang¹, Peng-Li Guo¹, Si-Qi Tao¹, Meng-Nan Zeng¹, Xiao-Ke Zheng², Wei-Sheng Feng³

Affiliations

¹ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, P.R. China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, P. R. China.
² School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, P.R. China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, P. R. China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China. Zhengzhou 450046, P.R. China.
³ School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, P.R. China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, P. R. China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China. Zhengzhou 450046, P.R. China. Electronic address: [email protected].

PMID: 39761940
DOI: 10.1016/j.phytochem.2025.114382

Abstract

From the tuber of Alisma orientale (Sam.) Juzep. (Alismataceae), twenty-four compounds were isolated, including six (1, 2, 3, 10, 14, and 17) that were not yet characterized. Spectroscopic investigations (IR, UV, HRESIMS, and NMR) were used to clarify their structures, and the ECD spectra of two compounds (8 and 9) were interpreted to identify their absolute configurations. Through an apoptotic signaling pathway, compounds 7, 15, 17, and 19 decreased the level of apoptosis in lung epithelial cells, indicating that they may have potential anti-pulmonary fibrosis (anti-PF) activity.

Keywords: Alisma orientale (Sam.) Juzep.; Alismataceae; anti-PF activity; apoptotic signaling pathway; structure identification.