Abstract
Wnt信号通路分为经典通路和非经典通路，其对生物的发育、组织再生及细胞增殖等发挥着关键作用。散乱蛋白（dishevelled）作为Wnt/β-catenin信号通路的核心蛋白，可以促进经典Wnt通路的激活，调控Wnt通路的分支。新近研究发现散乱蛋白在消化系统肿瘤中异常表达。本文将对散乱蛋白在食管鳞状细胞癌、胃癌、结直肠癌中的表达、潜在作用机制及其病理意义进行综述，并探讨其在消化系统肿瘤中的诊断、治疗及预后价值。.
MeSH terms
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Carcinoma, Squamous Cell* / genetics
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Carcinoma, Squamous Cell* / metabolism
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Carcinoma, Squamous Cell* / pathology
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / metabolism
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Colorectal Neoplasms / pathology
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Digestive System Neoplasms / genetics
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Digestive System Neoplasms / metabolism
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Digestive System Neoplasms / pathology
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Dishevelled Proteins* / genetics
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Dishevelled Proteins* / metabolism
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Esophageal Neoplasms* / genetics
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Esophageal Neoplasms* / metabolism
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Esophageal Neoplasms* / pathology
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Esophageal Squamous Cell Carcinoma / metabolism
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Esophageal Squamous Cell Carcinoma / pathology
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Humans
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Stomach Neoplasms* / genetics
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Stomach Neoplasms* / metabolism
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Stomach Neoplasms* / pathology
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Wnt Signaling Pathway*
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beta Catenin* / metabolism
Substances
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Dishevelled Proteins
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beta Catenin