Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium

Md Julkar Nime; Hideki Yamamura; Masayuki Hayakawa; Nobuyasu Matsuura; Naoya Oku; Yasuhiro Igarashi

doi:10.1038/s41429-024-00794-4

Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium

J Antibiot (Tokyo). 2025 Jan 6. doi: 10.1038/s41429-024-00794-4. Online ahead of print.

Authors

Md Julkar Nime¹, Hideki Yamamura², Masayuki Hayakawa³, Nobuyasu Matsuura⁴, Naoya Oku¹, Yasuhiro Igarashi⁵

Affiliations

¹ Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.
² Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, Japan.
³ Yamanashi Prefectural University, Yamanashi, Japan.
⁴ Department of Bioscience, Faculty of Bioscience, Okayama University of Science, Okayama, Japan.
⁵ Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan. [email protected].

PMID: 39762556
DOI: 10.1038/s41429-024-00794-4

Abstract

Two new benzene-containing polyketides, cryptoic acids A (1) and B (2), along with a new acylated diketopiperazine designated cyclocryptamide (3), were isolated from the culture extract of Cryptosporangium sp. YDKA-T02. The absolute configuration of amino acid components in 3 was determined by Marfey's method. While 3 was not cytotoxic and inactive against microbial test strains, 1 and 2 showed PPARγ agonistic activity in a reporter gene assay and cytotoxicity against P388 murine leukemia cells.