[A Case of Metastatic Extragonadal Germ Cell Tumor Treated by Surgical Resection after Chemotherapy and Follow-Up Time : A Case Report]

Hinyokika Kiyo. 2024 Dec;70(12):457-460. doi: 10.14989/ActaUrolJap_70_12_457.
[Article in Japanese]

Abstract

The patient was a 21-year-old man with a shadow on a chest roentgenogram taken during a medical checkup. According to blood testing, thoracoabdominal computed tomography, head magnetic resonance imaging, and lung tumor biopsy, we diagnosed a primary retroperitoneal germ cell tumor with multiple lung and brain metastases. Induction chemotherapy (4 courses of Bleomycin, Etoposide and Cisplatin) was started immediately. Because tumor markers remained elevated, salvage chemotherapy (4 courses of paclitaxel, ifosfamide cisplatin) was administered. Since the tumor markers remained elevated third-line chemotherapy was considered. However, because the tumor markers continued to decrease gradually and the tumor continued to shrink on imaging, expectant management was given. Three months later, the tumor markers turned negative, and retroperitoneal lymph node dissection and resection of lung metastases were performed. No cancer cells were found in any of the tissue samples. Careful monitoring after completion of chemotherapy may spare unnecessary chemotherapy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / drug therapy
  • Brain Neoplasms* / secondary
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / pathology
  • Lung Neoplasms* / secondary
  • Male
  • Neoplasms, Germ Cell and Embryonal* / diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal* / drug therapy
  • Neoplasms, Germ Cell and Embryonal* / pathology
  • Neoplasms, Germ Cell and Embryonal* / surgery
  • Retroperitoneal Neoplasms* / diagnostic imaging
  • Retroperitoneal Neoplasms* / drug therapy
  • Retroperitoneal Neoplasms* / pathology
  • Retroperitoneal Neoplasms* / secondary
  • Retroperitoneal Neoplasms* / surgery
  • Young Adult