From multi-omics to predictive biomarker: AI in tumor microenvironment

Front Immunol. 2024 Dec 23:15:1514977. doi: 10.3389/fimmu.2024.1514977. eCollection 2024.

Abstract

In recent years, tumors have emerged as a major global health threat. An increasing number of studies indicate that the production, development, metastasis, and elimination of tumor cells are closely related to the tumor microenvironment (TME). Advances in artificial intelligence (AI) algorithms, particularly in large language models, have rapidly propelled research in the medical field. This review focuses on the current state and strategies of applying AI algorithms to tumor metabolism studies and explores expression differences between tumor cells and normal cells. The analysis is conducted from the perspectives of metabolomics and interactions within the TME, further examining the roles of various cytokines. This review describes the potential approaches through which AI algorithms can facilitate tumor metabolic studies, which offers a valuable perspective for a deeper understanding of the pathological mechanisms of tumors.

Keywords: artificial intelligence; interactions; metabolomics; tumor cells; tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Animals
  • Artificial Intelligence*
  • Biomarkers, Tumor* / metabolism
  • Humans
  • Metabolomics* / methods
  • Multiomics
  • Neoplasms* / diagnosis
  • Neoplasms* / metabolism
  • Tumor Microenvironment*

Substances

  • Biomarkers, Tumor

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (32270633, 22005343), the Shenzhen Science and Technology Program (ZDSYS20220606101604009, KCXFZ20201221173008022), the Cooperation Fund of CHCAMS and SZCH (CFA202201010), the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academic of Medical Sciences and Peking Union Medical College, Shenzhen (E010124001, SZ2020ZD004).