The application of deep learning in early enamel demineralization detection

PeerJ. 2025 Jan 2:13:e18593. doi: 10.7717/peerj.18593. eCollection 2025.

Abstract

Objective: The study aims to develop a diagnostic model using intraoral photographs to accurately detect and classify early detection of enamel demineralization on tooth surfaces.

Methods: A retrospective analysis was conducted with 208 patients aged 14 to 44. A total of 624 high-quality digital images captured under standardized conditions were used to construct a deep learning model based on the Mask region-based convolutional neural network (Mask R-CNN). The model was trained to automate the detection of enamel demineralization. Its performance was compared to two junior dentists' diagnostic abilities.

Results: The model achieved an F1-score of 0.856 for detecting demineralized teeth on the validation set, a metric that reflects comprehensive diagnostic performance, demonstrating performance close to that of senior dentists. With the the model's assistance, the junior dentists' average F1-scores improved significantly-from 0.713 and 0.689 to 0.897 and 0.949, respectively (p < 0.05). The model accurately segmented tooth surfaces and detected demineralized areas, allowing for precise detection of demineralized areas and monitoring of lesion progression.

Conclusion: Deep learning can accurately segment tooth surfaces and lesion contours, enhancing the precision, accuracy, and efficiency of enamel demineralization diagnosis and area delineation.

Keywords: Artificial intelligence; Deep learning; Diagnostic imaging; Tooth demineralization.

MeSH terms

  • Adolescent
  • Adult
  • Deep Learning*
  • Dental Enamel / diagnostic imaging
  • Dental Enamel / pathology
  • Female
  • Humans
  • Male
  • Neural Networks, Computer
  • Photography, Dental / methods
  • Retrospective Studies
  • Tooth Demineralization* / diagnosis
  • Tooth Demineralization* / pathology
  • Young Adult

Grants and funding

This study was funded by the National Natural Science Foundation (32271364) and (31971240), the Major Special Science and Technology Project of Sichuan Province (grant no. 2022ZDZX0031), the Angelalign Scientific Research Fund (grant number SDTS21–4–01), and the Clinical Research Project of West China Hospital of Stomatology, Sichuan University (LCYJ2019-22). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.