Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG

Nicholas T Trapp; Xianqing Liu; Zhuoran Li; Joel Bruss; Corey J Keller; Aaron D Boes; Jing Jiang

doi:10.1101/2024.12.20.629857

Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG

bioRxiv [Preprint]. 2024 Dec 26:2024.12.20.629857. doi: 10.1101/2024.12.20.629857.

Authors

Nicholas T Trapp^{1

2}, Xianqing Liu³, Zhuoran Li³, Joel Bruss³, Corey J Keller^{4

5

6}, Aaron D Boes^{1

2

3

7}, Jing Jiang^{1

2

3}

Affiliations

¹ University of Iowa Department of Psychiatry, Iowa City, IA, USA.
² Iowa Neuroscience Institute, Iowa City, IA, USA.
³ University of Iowa Stead Family Department of Pediatrics, Iowa City, IA, USA.
⁴ Stanford University Department of Psychiatry and Behavioral Sciences, Stanford, CA, USA.
⁵ Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
⁶ Veterans Affairs Palo Alto Healthcare System, and the Sierra Pacific Mental Illness, Research, Education, and Clinical Center (MIRECC), Palo Alto, CA, USA.
⁷ University of Iowa Department of Neurology, Iowa City, IA, USA.

Abstract

Transcranial magnetic stimulation combined with intracranial local field potential recordings in humans (TMS-iEEG) represents a new method for investigating electrophysiologic effects of TMS with spatiotemporal precision. We applied TMS-iEEG to the dorsolateral prefrontal cortex (dlPFC) in two subjects and demonstrate evoked activity in the subgenual anterior cingulate cortex (sgACC). This study provides direct electrophysiologic evidence that dlPFC TMS, as targeted for depression treatment, can modulate brain activity in the sgACC.

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Preprint

Abstract

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