The Harmonized Cognitive Assessment Protocol (HCAP) is a detailed battery assessing cognition among older people used by studies across the world. Data harmonization is a key priority for HCAP studies. We used a mixed-methods approach using established theories from the existing literature detailing the methodologies of longitudinal studies and from the implementation of HCAP in four English-speaking studies adopting the same protocol. Through a detailed investigation involving the English Longitudinal Study of Ageing (ELSA), the Health and Retirement Study (HRS), The Irish Longitudinal Study on Ageing (TILDA), and the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), we identified 60 factors contributing to the development of a conceptual framework for the evaluation and implementation of HCAP. We present this framework and a prototype checklist as a tool for providing a transparent and structured approach to improve data quality, cross-country comparability and for identifying, mitigating, and monitoring sources of bias. The framework consisting of four broad headings: (1) Organisation and design, (2) Competency of personnel and systems, (3) Implementation and outputs, and (4) Feedback and communication. Studies seeking to harmonize results in cross-national contexts should give operational aspects of fieldwork careful consideration as part of the harmonization process.