A biocompatible Ni(II) complex as an amyloid sensor for human PrP106-126 fibrillar aggregates

Rajat Saini; Rahul Chauhan; Sain Singh; Saakshi Saini; Govinda R Navale; Abhishek Panwar; Prashant Kukreti; Imtiaz Ahmed; Partha Roy; Kaushik Ghosh

doi:10.1039/d4cc04335a

A biocompatible Ni(II) complex as an amyloid sensor for human PrP_106-126 fibrillar aggregates

Chem Commun (Camb). 2025 Jan 7. doi: 10.1039/d4cc04335a. Online ahead of print.

Authors

Affiliations

¹ Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India. [email protected].
² Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee 247667, India. [email protected].
³ Department of Chemistry, National Institute of Technology Manipur, Langol-795004, India.

PMID: 39764576
DOI: 10.1039/d4cc04335a

Abstract

KRS-1, a biocompatible nickel(II) complex, is introduced as a potent fluorescent probe for PrP_106-126 fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP_106-126 aggregation. Fluorescence microscopy confirms its efficacy in identifying PrP_106-126 fibrillar aggregates in HT-22 cells.