Association Between Coffee Intake and Common Mental Disorders: Insights From Genetic Analysis

CNS Neurosci Ther. 2025 Jan;31(1):e70213. doi: 10.1111/cns.70213.

Abstract

The study found a significant causal relationship between coffee intake and obsessive-compulsive disorder, showing a negative correlation. There was no causal relationship between coffee intake and other mental disorders. The sensitivity analysis test found no pleiotropy affecting the results, and no single nucleotide polymorphism had a major impact on the robustness of the results, indicating that the results are stable and reliable.

Keywords: Coffee intake; Mendelian randomization; Mental disorders; Obsessive‐compulsive disorder.

Publication types

  • Letter

MeSH terms

  • Adult
  • Coffee*
  • Female
  • Humans
  • Male
  • Mental Disorders* / epidemiology
  • Mental Disorders* / genetics
  • Obsessive-Compulsive Disorder / genetics
  • Polymorphism, Single Nucleotide* / genetics

Substances

  • Coffee