Particle manipulation is a central technique that enhances numerous scientific and medical applications by exploiting micro- and nanoscale control within fluidic environments. In this review, we systematically explore the multifaceted domain of particle manipulation under the influence of various X-force fields, integral to lab-on-a-chip technologies. We dissect the fundamental mechanisms of hydrodynamic, gravitational, optical, magnetic, electrical, and acoustic forces and detail their individual and synergistic applications. In particular, our discourse extends to advanced multi-modal manipulation strategies that harness the combined power of these forces, revealing their enhanced efficiency and precision in complex assays and diagnostic frameworks. The integration of cutting-edge technologies such as artificial intelligence and autonomous systems further enhances the capabilities of these microfluidic platforms, leading to transformative innovations in personalized medicine and point-of-care diagnostics. This review not only highlights current technological advances, but also forecasts the trajectory of future developments, emphasizing the escalating precision and scalability essential for advancing lab-on-a-chip applications.