Fanlian Huazhuo formula: A promising therapeutic approach for metabolic associated steatotic liver disease

World J Gastroenterol. 2025 Jan 7;31(1):100250. doi: 10.3748/wjg.v31.i1.100250.

Abstract

This article reviews the study, "Fanlian huazhuo formula alleviates high-fat-diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway" published in the World Journal of Gastroenterology. The study explores the therapeutic potential of Fanlian Huazhuo formula (FLHZF) in treating metabolic-associated steatotic liver disease (MASLD), demonstrating that FLHZF reduces lipid accumulation, oxidative stress, and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and autophagy. This editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.

Keywords: Autophagy; Fanlian Huazhuo formula; Lipid metabolism; Metabolic associated steatotic liver disease; Oxidative stress.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Autophagy* / drug effects
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Drugs, Chinese Herbal* / pharmacology
  • Drugs, Chinese Herbal* / therapeutic use
  • Humans
  • Lipid Metabolism* / drug effects
  • Liver* / drug effects
  • Liver* / metabolism
  • Liver* / pathology
  • Non-alcoholic Fatty Liver Disease* / drug therapy
  • Non-alcoholic Fatty Liver Disease* / metabolism
  • Non-alcoholic Fatty Liver Disease* / pathology
  • Oxidative Stress* / drug effects
  • Signal Transduction* / drug effects

Substances

  • Drugs, Chinese Herbal