Antioxidative and mineral-binding food-derived peptides: Production, functions, metal complexation conditions, and digestive fate

The discovery of food-derived biopeptides is becoming increasingly prevalent in the scientific community. Some peptides possess multiple biological functions that can confer health benefits through various mechanisms following ingestion. The present review targets food-derived antioxidant and mineral-binding peptides (AMBPs) including their production procedure i.e., enzymolysis, separation, and purification (through membrane separation, gel filtration, ion exchange chromatography, and high-performance liquid chromatography), followed by mass spectrometry for identification. The most effective AMBPs exhibit radical scavenging activity, detoxification of excess metals, and reduction of lipid peroxidation to facilitate mineral bioavailability. The metal complexation of AMBPs necessitates an optimal metal-to-peptide ratio, specific ligands, precursors, and complexation reactions. The bioavailability and absorbability mechanisms of AMBPs are also elucidated, encompassing gastrointestinal stability, binding mode, and cell absorption machinery. Ultimately, further considerations regarding additional research on AMBPs are provided, which will assist researchers in conducting more comprehensive studies to promote the effective and safe use of AMBPs.