Characterization, adsorption kinetic and in vitro release behavior of curcumin loaded with porous mannitol and porous lactose: Template agent method vs. Pore-forming agent method

Polyvinylpyrrolidone K30 was used as the templating agent, and ammonium bicarbonate was used as the pore-forming agent to make porous mannitol and porous lactose by the template and pore-forming agent method, respectively. Compared with the template method, the porous particles prepared by the pore-forming agent method have larger pore diameter (320.276 nm and 250.528 nm) and specific surface area (1.018 m²/g and 0.913 m²/g). The molecular docking results showed that mannitol/lactose interacted with curcumin and adhered to each other through hydrogen bonding. The adsorption kinetics process of porous mannitol and porous lactose prepared by template agent, pore-forming agent and curcumin were different. Among the curcumin-loaded porous particles prepared by the two methods, the curcumin-loaded porous lactose prepared by the pore-forming agent method had the fastest release rate and the highest cumulative release rate (95 %). Curcumin releases consistent with the Peppas release kinetics model and the diffusion mechanism.