The ubiquitin-proteasome system is key for proteostasis and its disruption can induce several cellular adaptations. Here, we summarize the range of cellular responses that are induced by perturbation of distinct components of the ubiquitin-proteasome system, and how proteasome stress in a tissue can induce systemic responses in distant tissues.
Keywords: E2 ubiquitin-conjugating enzymes; UBA1; ingrained stress response; proteasome; systemic stress response; ubiquitination.
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