Implementation of Diversity, Equity, Inclusion, and Respect (DEIR) is crucial for supporting students in a culturally safe environment, reducing bias, fostering respect, broadening perspectives, enhancing collaboration, and improving education in science. DEIR with Indigenous reconciliation incorporates Indigenous-based DEIR initiatives as a response to the Truth and Reconciliation Commission (TRC) in Canada to acknowledge the intergenerational trauma and mistrust toward colonial institutions such as universities. Universities can advance reconciliation by incorporating DEIR with Indigenous reconciliation into everyday practices. Indigenous students are significantly less likely to attain degrees in science, technology, engineering, and mathematics (STEM). The lack of Indigenous representation in STEM significantly hinders the inclusion of Indigenous perspectives in scientific processes and decision-making. A collaborative effort is essential to improve Indigenous student recruitment in science programs. Scientists need to educate themselves on the colonial legacies of Indian Residential Schools (IRSs) and Indian Hospitals (IHs), as well as on the biases and barriers that Indigenous students face. While this paper focuses on several Canadian examples, it highlights challenges and traumas that are similarly faced by Indigenous students worldwide. Therefore, supervisors and research groups should actively participate in training sessions and develop strategies aimed at preventing discrimination and fostering inclusivity. This paper highlights the importance of DEIR with Indigenous reconciliation in university science programs and addresses issues of recruiting Indigenous students. The "Calls to Action" outlined in this paper will help scientists and educators understand barriers faced by Indigenous students, advocate for lifelong learning and social stewardship, and foster a more inclusive scientific environment.