Dabie bandavirus and Mycoplasma pneumoniae co-infection: a case report

BMC Infect Dis. 2025 Jan 9;25(1):47. doi: 10.1186/s12879-024-10392-2.

Abstract

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV). We report a case of DBV and Mycoplasma pneumoniae (MP) co-infection.

Case presentation: Here we reported a 57-year-old healthy male who was admitted with the presentations of fever, cough, hemoptysis, and hypotension. Laboratory investigations revealed thrombocytopenia, leukopenia, and organ dysfunction of liver and kidney. Seroconversion from Mycoplasma IgM antibody to IgG was recorded, and SFTS was confirmed through metagenomic next-generation sequencing. In addition, hemophagocytic lymphohistiocytosis was diagnosed in the context of DBV and MP coinfection. The patient exhibited a rapid recovery following treatment with omadacycline and essential symptomatic and supportive treatment.

Conclusions: We firstly reported a case with DBV and MP coinfection, which reminded us that the symptoms of DBV infection were bewildering and easy to miss diagnosis when it was co-infection with other etiologies.

Keywords: Dabie Bandavirus; Mycoplasma pneumoniae; Coinfection; Hemophagocytic lymphohistiocytosis; Metagenomic next-generation sequencing.

Publication types

  • Case Reports

MeSH terms

  • Coinfection* / microbiology
  • Coinfection* / virology
  • Humans
  • Immunoglobulin M / blood
  • Male
  • Middle Aged
  • Mycoplasma pneumoniae* / genetics
  • Mycoplasma pneumoniae* / isolation & purification
  • Pneumonia, Mycoplasma* / complications
  • Pneumonia, Mycoplasma* / diagnosis
  • Pneumonia, Mycoplasma* / drug therapy
  • Pneumonia, Mycoplasma* / microbiology
  • Severe Fever with Thrombocytopenia Syndrome / diagnosis
  • Severe Fever with Thrombocytopenia Syndrome / virology

Substances

  • Immunoglobulin M