Molecular characterization of swine acute diarrhea syndrome coronavirus detected in Vietnamese pigs

Vet Res. 2025 Jan 9;56(1):4. doi: 10.1186/s13567-024-01445-0.

Abstract

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine coronavirus that was recently identified in southern China in 2017. At present, there is a lack of nationwide epidemiological investigations of the newly emerged SADS-CoV. Because Vietnam is geographically adjacent to southern China, many diseases have spread from China to Vietnam. To assess SADS-CoV transmission to Vietnam, we conducted a retrospective study to detect SADS-CoV in samples collected from pig farms in northern Vietnam. Among the 69 fecal samples tested, 5 were positive for SADS-CoV. The spike gene sequence showed high genetic homology with strains circulating in China. Our study is the first to show that SADS-CoV has spread from China to Vietnam and highlights the need for global epidemiological investigations of SADS-CoV.

Keywords: Swine acute diarrhea syndrome coronavirus; Vietnam; pig; spike.

MeSH terms

  • Alphacoronavirus / genetics
  • Alphacoronavirus / isolation & purification
  • Animals
  • China / epidemiology
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / veterinary
  • Coronavirus Infections* / virology
  • Feces / virology
  • Phylogeny
  • Retrospective Studies
  • Southeast Asian People
  • Swine
  • Swine Diseases* / epidemiology
  • Swine Diseases* / virology
  • Vietnam / epidemiology

Supplementary concepts

  • Swine acute diarrhea syndrome coronavirus