Benign Lung Adenoma Mimicking an Adenocarcinoma With EML4-ALK Gene Fusion

Jonathan R Hyde; Elham Kamangar; Alexander E Ladenheim; David T Cooke

doi:10.1016/j.atssr.2022.10.006

Benign Lung Adenoma Mimicking an Adenocarcinoma With EML4-ALK Gene Fusion

Ann Thorac Surg Short Rep. 2022 Oct 18;1(1):137-139. doi: 10.1016/j.atssr.2022.10.006. eCollection 2023 Mar.

Authors

Jonathan R Hyde¹, Elham Kamangar², Alexander E Ladenheim², David T Cooke¹

Affiliations

¹ Division of General Thoracic Surgery, Department of Surgery, University of California, Davis Health, Sacramento, California.
² Department of Pathology and Laboratory Medicine, University of California, Davis Health, Sacramento, California.

Abstract

Bronchiolar adenoma is a benign neoplastic process thought to be derived from the bronchiolar epithelium. Particularly in small biopsy specimens, this entity can mimic lung cancer with important implications for management. We report the case of a 33-year-old man with a right upper lobe lung nodule, with initial biopsy identifying an adenocarcinoma with EML4-ALK gene fusion. After being considered for neoadjuvant targeted therapy trials, the patient underwent a lobectomy. On postoperative histologic evaluation, the patient was found to have a benign bronchiolar adenoma.

Publication types

Case Reports