Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis

Emodin, as a natural active ingredient, has shown great application potential in the fields of medicine, food and cosmetics due to its unique pharmacological effects, such as anti-inflammatory, antioxidant, anti-cancer, etc. In recent years, with the development of science and technology and the increase of people's demand for natural medicine, emodin research has been paid more and more attention by the global scientific research community. The bibliometric analysis of emodin and the construction of knowledge map are still blank. We searched the publications of emodin related studies in the Web of Science Core Collection (WoSCC) database from 2004 to 2024 and conducted a bibliometric analysis. Data processing was done using the R packages Bibliometrix, VOSviewer and CiteSpace. The consensus identified 4,125 emodin related articles from multiple countries, with China being the main contributor. The number of publications in this field is increasing year by year. China Medical University, the Chinese Academy of Sciences, and Nanjing University of Traditional Chinese Medicine are all prominent research institutions in this field. The Journal of ethnopharmacology published the most articles on the subject. The total number of authors of these articles has reached 14,991, among which Yi Wang is the author with the most output and Xiaoxv Dong is the author with the most cited times. "emodin", "apoptosis", and "liver injury" were the main research focuses. Topics such as "pharmacology", "photodynamic therapy", "advancing drug discovery" and "gallbladder cancer cell" may represent emerging areas of research in medicine. The results of this study help to identify the latest research frontiers and hot topics, and provide a valuable reference for the study of emodin family.