Research progress on the structural and anti-colorectal malignant tumor properties of Shikonin

Jinghua Chen; Jie Liu; Weiwei Nie; Xingqin Hou; Xi Zhang; Chao Liu; Linxin Si; Mingzhu Zhang; Shutao Xu; Qi Xie; Jing Liang; Yan Li

doi:10.4103/jcrt.jcrt_933_24

Research progress on the structural and anti-colorectal malignant tumor properties of Shikonin

J Cancer Res Ther. 2024 Dec 1;20(7):1957-1963. doi: 10.4103/jcrt.jcrt_933_24. Epub 2025 Jan 10.

Authors

Jinghua Chen^{1

2}, Jie Liu³, Weiwei Nie¹, Xingqin Hou⁴, Xi Zhang², Chao Liu², Linxin Si², Mingzhu Zhang², Shutao Xu², Qi Xie¹, Jing Liang¹, Yan Li¹

Affiliations

¹ Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China.
² Department of Oncology, People's Hospital of Zhangdian District, Zibo, China.
³ Department of Pediatric Intensive Care Unit, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
⁴ South Ward, The Second Hospital of Shandong University, Jinan, China.

PMID: 39792404
DOI: 10.4103/jcrt.jcrt_933_24

Abstract

Colorectal cancer is the third most prevalent malignant tumor worldwide. Despite the advancements in surgical procedures and treatment options, CRC remains a considerable cause of cancer-related mortality. Shikonin is a naphthoquinone compound that exhibits multiple biological activities, including anti-inflammatory and anti-tumor effects as well as wound healing promotion. Recently, Shikonin has been increasingly used in basic research on colorectal malignant tumors. Therefore, we explored the mechanisms of action and structural improvements of Shikonin in colorectal cancer through a literature review to provide valuable insights for the advancement of research and development of related pharmaceuticals.