Recent research progress on microRNAs from mesenchymal stem cell-derived exosomes for tumor therapy: A review

Yifan Jiang; Xue Gao; Xuezhen Zheng; Yan Lu; Minghan Zhang; Wenxuan Yan; Wentao Pan; Hengli Li; Yueying Zhang

doi:10.4103/jcrt.jcrt_540_23

Recent research progress on microRNAs from mesenchymal stem cell-derived exosomes for tumor therapy: A review

J Cancer Res Ther. 2024 Dec 1;20(7):1974-1982. doi: 10.4103/jcrt.jcrt_540_23. Epub 2025 Jan 10.

Authors

Yifan Jiang^{1

2}, Xue Gao^{2

3}, Xuezhen Zheng^{1

2}, Yan Lu¹, Minghan Zhang⁴, Wenxuan Yan⁴, Wentao Pan⁴, Hengli Li⁵, Yueying Zhang^{1

2}

Affiliations

¹ Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China.
² Department of Pathophysiology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
³ Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
⁴ School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
⁵ Emergency Department, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.

PMID: 39792406
DOI: 10.4103/jcrt.jcrt_540_23

Abstract

Mesenchymal stem cells (MSCs) are a class of protocells that can differentiate into various cell types and have robust replication and renewal capabilities. MSCs secrete various nutritional factors to regulate the microenvironment of tumor tissues. The mechanism by which they inhibit or promote tumor growth may be closely related to MSC-derived exosomes (MSC-Exo). However, the role of MSC-Exo vesicles in tumors remains controversial. This review discusses the potential applications of microRNAs in exosomes derived from MSCs in treating tumors.