High mobility emissive organic semiconductors (HMEOSCs) are a kind of unique semiconducting material that simultaneously integrates high charge carrier mobility and strong emission features, which are not only crucial for overcoming the performance bottlenecks of current organic optoelectronic devices but also important for constructing high-density integrated devices/circuits for potential smart display technologies and electrically pumped organic lasers. However, the development of HMEOSCs is facing great challenges due to the mutually exclusive requirements of molecular structures and packing modes between high charge carrier mobility and strong solid-state emission. Encouragingly, considerable advances on HMEOSCs have been made with continuous efforts, and the successful integration of these two properties within individual organic semiconductors currently presents a promising research direction in organic electronics. Representative progress, including the molecular design of HMEOSCs, and the exploration of their applications in photoelectric conversion devices and electroluminescent devices, especially organic photovoltaic cells, organic light-emitting diodes, and organic light-emitting transistors, are summarized in a timely manner. The current challenges of developing HMEOSCs and their potential applications in other related devices including electrically pumped organic lasers, spin organic light-emitting transistors are also discussed. We hope that this perspective will boost the rapid development of HMEOSCs with a new mechanism understanding and their wide applications in different fields entering a new stage.