Two undescribed compounds, including one monoterpene (1) and one sesquiterpene (2), together with eleven known compounds were isolated from Platycladus orientalis. The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity. The results showed that compounds 5-6, 9 and 12 exhibited NLRP3-inflammasome inhibitory activity.
Keywords: Platycladus orientalis; anti-inflammatory activity; monoterpene; sesquiterpene.