Effects of allergic diseases on social-emotional development in children at 12 months of age: A Prospective Cohort Study

Objectives: The link between allergic diseases and deficits in children's neurodevelopment has been suggested, but it remains unclear regarding the allergy-related effects on social-emotional development in early life. Our study aimed to explore the association between allergic diseases and social-emotional development during infancy using a prospective study.

Methods: 937 infants at 6 months were recruited from two community hospitals in Shanghai, of which 805 infants followed up at 12 months. The outcome was social-emotional concern, defined by Ages & Stages Questionnaire: Social-Emotional and personal social domain from Ages & Stages Questionnaire with established cutoffs. Allergic diseases were assessed using modified International Study of Asthma and Allergies in Childhood core questionnaire. Allergy patterns were classified based on time of onset and persistence as "Never", "Transient" (allergy at age of 0-6 months only or 7-12 months only), "Persistent" (allergy at age of 0-6 and 7-12 months).

Results: 8.45 % of 12-month infants exhibited social-emotional concerns. Infants had increased risk of social-emotional concerns at 12 months who suffered allergic diseases during 0-12 months (adjusted odd ratio [aOR], 2.22; 95 % confidence interval [CI], 1.33-3.70), 7-12 months (aOR[95%CI]: 2.07 [1.21, 3.57]) and 0-6 months (aOR[95%CI]: 1.90 [1.12, 3.21]). Additionally, infants with persistent allergy had a 161 % higher risk of social-emotional concern (aOR[95%CI]: 2.61 [1.29, 5.28], P = 0.008) compared to infants without allergy (P for trend = 0.001).

Conclusion: Allergic infants were more likely to experience social-emotional concerns, particularly for those with persistent allergy. To optimize social-emotional development, we highlight regular monitoring of mental health and effective management of allergy during infancy.