Abstract
People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.
© 2025. The Author(s).
MeSH terms
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Adult
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Atrial Remodeling*
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Female
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HIV Infections* / blood
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Heart Atria / diagnostic imaging
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Heart Failure* / blood
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Heart Failure* / epidemiology
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Proteome / metabolism
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Proteomics* / methods
Grants and funding
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U01-DA036297/U.S. Department of Health & Human Services | National Institutes of Health (NIH)
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U01-HL146201/U.S. Department of Health & Human Services | National Institutes of Health (NIH)
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U01-HL146193, U01-HL146240, U01-HL146205/U.S. Department of Health & Human Services | National Institutes of Health (NIH)
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P30AI094189/U.S. Department of Health & Human Services | National Institutes of Health (NIH)
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K24 AI120834/AI/NIAID NIH HHS/United States
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ZIAAG000297/U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
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HL007227/U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
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1K23HL166770-01/U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
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HHSN2682015000031, HSN26800004, HHSN268201600034I/U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)