Objective: To investigate the effect of Brucea javanica Oil combined with chemotherapy on serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), immune mechanism, and prognosis in patients with lung cancer and provide a reference for its clinical diagnosis and treatment.
Methods: This study involved 112 lung cancer patients from June 2019 to January 2022 at Shanghai Guanghua Hospital. They were randomly divided into two groups: control (chemotherapy only) and observation (chemotherapy + Brucea javanica oil emulsion). Each treatment lasted three weeks for a total of four courses. Pre- and post-treatment comparisons were made for tumor markers, immune function, and quality of life. Clinical outcomes and adverse reactions were analyzed.
Results: The clinical efficacy of the observation group was significantly higher than that of the control group (P < .05). Compared to the pre-treatment levels, both groups exhibited significant decreases in serum levels of carcinoembryonic antigen (CEA), cytokeratin fragment 21-1 (CYFRA21-1), cancer antigen 125 (CA125), phosphorylated extracellular signal-regulated kinase (pERK), neuron-specific enolase (NSE), and vascular endothelial growth factor (VEGF). The reduction in these serum markers was more pronounced in the observation group (P < .05). After treatment, both groups demonstrated significant increases in CD8+ and CD3+ lymphocyte levels, as well as CD4+ lymphocyte levels and the CD4+/CD8+ ratio. However, the improvement in these immune indicators was more significant in the control group (P < .05). Furthermore, the quality of life, as assessed by the Quality-of-Life Questionnaire-Lung Cancer Module 13(QLQ-LC13) questionnaire, showed significant improvements in both groups after treatment. The observation group exhibited a more significant decrease in the QLQ-LC13 scores, indicating a better quality of life post-treatment (P < .05).
Conclusion: Brucea javanica oil combined with GP chemotherapy can effectively reduce the synthesis and secretion of tumor-related markers, improve immune function, reduce the incidence of adverse reactions, improve the prognosis and quality of life, and enhance the curative effect, which has a certain clinical application value.