Metabolic Profiling: A Perspective on the Current Status, Challenges, and Future Directions

Helen G Gika; Georgios Theodoridis; Ian D Wilson

doi:10.1007/978-1-0716-4334-1_1

Metabolic Profiling: A Perspective on the Current Status, Challenges, and Future Directions

Methods Mol Biol. 2025:2891:1-14. doi: 10.1007/978-1-0716-4334-1_1.

Authors

Helen G Gika^{1

2}, Georgios Theodoridis^{2

3

4}, Ian D Wilson⁵

Affiliations

¹ Department of Medicine, Aristotle University, Thessaloniki, Greece.
² Biomic Auth, Bioanalysis and Omics Laboratory, Center for Interdisciplinary Research and Innovation, Aristotle University, Thessaloniki, Greece.
³ Department of Chemistry, Aristotle University, Thessaloniki, Greece.
⁴ ThetaBiomarkers, Center for Interdisciplinary Research, and Innovation (CIRI-AUTH), Aristotle University, Balkan Center, Thessaloniki, GR, Greece.
⁵ Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.

PMID: 39812974
DOI: 10.1007/978-1-0716-4334-1_1

Abstract

Metabolic profiling continues to develop, and research is now conducted on this topic globally in hundreds of laboratories, from small groups up to national centers and core facilities. Here we briefly provide a perspective on the current status and challenges facing metabolic phenotyping (metabonomics/metabolomics) and consider future directions for this important area of biomarker and systems biology research.

Keywords: Biomarker discovery; Metabolic markers; Metabolic phenotyping; Metabolic profiling; Metabolomics; Metabonomics.

Publication types

Review

MeSH terms

Animals
Biomarkers* / metabolism
Humans
Metabolome*
Metabolomics* / methods
Phenotype
Systems Biology / methods

Substances

Biomarkers