Right Ventricular Function and Outcomes Stratified by the Effective Regurgitant Orifice Area in Secondary Tricuspid Regurgitation

Background: In patients with moderate and severe secondary tricuspid regurgitation (STR), the effective regurgitant orifice area (EROA), corrected using the proximal isovelocity surface area (PISA) method for tricuspid valve leaflet tethering and low TR jet velocities, has an unclear threshold for identifying high-risk patients. This study aimed to establish a risk-based EROA cutoff and assess the impact of right ventricular (RV) remodeling on outcomes in low-risk STR patients according to EROA.

Methods: We included 513 consecutive outpatients (age 75±13 years, 47% male) with moderate and severe STR. Patients were categorized by a spline-derived EROA threshold into low (≤0.47cm²) and high (>0.47cm²) risk groups. The primary endpoint was a composite of heart failure hospitalization and death.

Results: Over a follow-up period of 18±15 months, 195 patients reached the composite endpoint. Kaplan-Meier analysis showed a significantly higher event rate in high-risk patients (54±6% vs. 30±7%, p <0.0001). An EROA>0.47cm² was associated with a two-fold increased risk (Hazard Ratio [HR]:2.08, 95% Confidence Interval [CI]: 1.56-2.77, p<0.0001). This association remained significant after multivariable adjustment (adjusted HR:1.01, 95%CI:1.00-1.02, p<0.0001). In the low-risk group, poor outcomes were linked to RV dilation or dysfunction. Two-year event rates for RV parameters were as follows: RV end-diastolic volume>90 mL/m² (42±4%), RV end-systolic volume>46 mL/m² (51±4%), RV ejection fraction<45% (44±4%), and RV forward stroke volume/RV end-systolic volume<0.40 (47±4%).

Conclusions: EROA independently predicts outcomes in STR. For low-risk patients by EROA, evaluating RV function and RV-PA coupling enhances risk stratification.