Nasal microbiota transplantation: a gateway to novel treatments

Sudhanshu Shekhar; Martin Schwarzer; Achal Dhariwal; Fernanda Cristina Petersen

doi:10.1016/j.tim.2024.12.010

Nasal microbiota transplantation: a gateway to novel treatments

Trends Microbiol. 2025 Jan 14:S0966-842X(24)00326-3. doi: 10.1016/j.tim.2024.12.010. Online ahead of print.

Authors

Sudhanshu Shekhar¹, Martin Schwarzer², Achal Dhariwal³, Fernanda Cristina Petersen⁴

Affiliations

¹ Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic. Electronic address: [email protected].
² Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic.
³ Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Norway.
⁴ Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Norway. Electronic address: [email protected].

PMID: 39814666
DOI: 10.1016/j.tim.2024.12.010

Abstract

Two recent studies have highlighted the potential of nasal microbiota transplantation (NMT) to treat chronic rhinosinusitis (CRS). Here we evaluate these findings and propose that lessons from fecal microbiota transplantation (FMT) could guide NMT development, with possible implications for combating antimicrobial resistance in respiratory infections.

Keywords: NMT; antimicrobial resistance; chronic rhinosinusitis; dysbiosis; nasal microbiota.