Advancing Small Nucleic Acid Drug Delivery: From Stability Challenges to Novel Therapeutic Applications

Curr Drug Deliv. 2025 Jan 14. doi: 10.2174/0115672018370847250110094907. Online ahead of print.

Md Sadique Hussain¹, Ajay Singh Bisht², Haider Ali^{3

4}, Gaurav Gupta^{5

6}

¹ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand 248007, India.
² School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun 248001, Uttarakhand, India.
³ Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 602105, India.
⁴ Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.
⁵ Centre for Research Impact & Outcome-Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India.
⁶ Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE.

No abstract available

Keywords: Drug delivery; Exosome-based delivery; GalNAc conjugation; Hybrid delivery platforms; Lipid nanoparticles (LNPs); RNA modification..