Optimizing antibiotic stewardship and reducing antimicrobial resistance in Central Asia: A study protocol for evidence-based practice and policy

PLoS One. 2025 Jan 16;20(1):e0307784. doi: 10.1371/journal.pone.0307784. eCollection 2025.

Abstract

Antimicrobial resistance (AMR) poses a significant global health challenge, prompting the World Health Organization (WHO) to stress the importance of monitoring antibiotic consumption and sales to address AMR effectively. This study protocol aims to optimize antibiotic stewardship and combat AMR in Central Asia through evidence-based practices and policies. The protocol includes objectives such as conducting systematic reviews of interventions to promote judicious antibiotic use, assessing antibiotic consumption trends, and investigating antibiotic overuse practices among healthcare providers. The study aims to raise awareness among stakeholders to enhance appropriate antibiotic prescribing practices. By establishing regulatory frameworks, monitoring policies' effectiveness, and providing training programs for healthcare professionals, this study seeks to contribute to the global efforts in combating AMR and promoting prudent antibiotic use.

MeSH terms

  • Anti-Bacterial Agents* / therapeutic use
  • Antimicrobial Stewardship* / methods
  • Asia
  • Asia, Central
  • Drug Resistance, Bacterial
  • Evidence-Based Practice*
  • Health Policy
  • Humans

Substances

  • Anti-Bacterial Agents

Grants and funding

This work was supported by Nazarbayev University under Collaborative Research Program Grant No. 211123CRP1609 awarded to YS (PI) and LL (co-PI).