The Novel HLA-C*03:681 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual

HLA. 2025 Jan;105(1):e70021. doi: 10.1111/tan.70021.

Authors

Xian-Sheng Luo¹, Zhi-Cong Xie², Li Ma², Xiao-Zhuang Hu², Juan Wang¹

Affiliations

¹ Department of Hematology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China.
² Department of Laboratory, Shanghai Tissuebank Biotechnology Co. Ltd, Shanghai, China.

PMID: 39822151
DOI: 10.1111/tan.70021

Abstract

The HLA-C*03:681 allele differs from HLA-C*03:02:02:01 by a single non-synonymous nucleotide change in exon 3.

Keywords: HLA‐C*03:681; novel allele; sequencing‐based typing.

© 2025 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Letter

MeSH terms

Alleles*
Asian People* / genetics
Base Sequence*
Codon
East Asian People
Exons*
HLA-C Antigens* / genetics
Histocompatibility Testing*
Humans
Polymorphism, Single Nucleotide
Sequence Alignment
Sequence Analysis, DNA* / methods

Substances

HLA-C Antigens
HLA-C*03 antigen
Codon