Flavonoid-rich extract of Paederia scandens (Lour.) Merrill improves hyperuricemia by regulating uric acid metabolism and gut microbiota

Yuyi Liu; Shanling Sheng; Linye Wu; Huixian Wang; Hui Xue; Ruimin Wang

doi:10.1016/j.foodchem.2025.142857

Flavonoid-rich extract of Paederia scandens (Lour.) Merrill improves hyperuricemia by regulating uric acid metabolism and gut microbiota

Food Chem. 2025 Jan 11:471:142857. doi: 10.1016/j.foodchem.2025.142857. Online ahead of print.

Authors

Yuyi Liu¹, Shanling Sheng¹, Linye Wu¹, Huixian Wang¹, Hui Xue¹, Ruimin Wang²

Affiliations

¹ Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
² Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China. Electronic address: [email protected].

PMID: 39823906
DOI: 10.1016/j.foodchem.2025.142857

Abstract

Paederia scandens (Lour.) Merrill flavonoid-rich extract (PSMF) has shown excellent xanthine oxidase (XOD) inhibitory activity in our previous study. However, the efficacy of PSMF in mitigating hyperuricemia (HUA) remains to be elucidated. In this study, we investigated the effects and mechanisms of PSMF on alleviating in HUA mice. The results showed that PSMF intervention reduced serum levels of uric acid (UA), creatinine (CRE), and blood urea nitrogen (BUN), and inhibited the activities of XOD and adenosine deaminase (ADA). In addition, PSMF treatment not only attenuated the inflammatory response and renal damage but also regulated the expression of UA synthesis genes and UA excretion genes. Finally, PSMF ameliorated gut microbiota dysbiosis in HUA mice by enriching the abundance of short-chain fatty acid (SCFA)-producing bacteria. In summary, PSMF appears to be a promising natural source for the prevention and treatment of HUA.

Keywords: Flavonoids; Gut microbiota; Hyperuricemia; Inflammation; Paederia scandens (Lour.) Merrill.