Immediate dental implant placement with and without Platelet-Rich Fibrin (PRF) in esthetic zone: A comparative study

Context: Biomaterials such as platelet-rich fibrin (PRF) have shown to improve healing and osseointegration.

Aims: The aim of this study was to clinically and radiographically evaluate and compare immediate implants placed with and without PRF.

Settings and design: This prospective and comparative study was conducted among 30 patients in the Department of Oral and Maxillofacial Surgery, Govt. Dental College and Hospital, Srinagar.

Materials and methods: Thirty subjects were randomly divided into two groups: group A or PRF group and group B or non-PRF group with fifteen patients in each group. Clinical parameters such as implant mobility and bleeding on probing were recorded. The radiographic parameters such as bone density in Hounsfield units (HU) and marginal bone loss (mm) were measured using cone-beam computed tomography (CBCT).

Statistical analysis used: For intergroup analysis of data, Student's independent t-test and Chi-square test were employed. The paired t-test and McNemar test were applied for intragroup analysis of data.

Results: No significant difference in the mean marginal bone level scores between PRF group and non-PRF group (intergroup) at baseline and at 3 months was observed. A Statistically significant difference was observed in the mean bone density (HU) in the PRF group (intragroup) between baseline and 3 months and also in bleeding on probing between baseline and 6 months in the PRF group (intragroup).

Conclusions: The results highlighted the promising but transitory effects of (PRF) membrane in immediate implants and showed an improvement in peri-implant bone density, which improves implant stability and subsequent long implant survival and prognosis.