Update to RIFM fragrance ingredient safety assessment, 4,8-dimethyl-7-nonen-2-ol, CAS Registry Number 40596-76-7

A M Api; A Bartlett; D Belsito; D Botelho; M Bruze; A Bryant-Friedrich; G A Burton Jr; M A Cancellieri; H Chon; M L Dagli; W Dekant; C Deodhar; K Farrell; A D Fryer; L Jones; K Joshi; A Lapczynski; M Lavelle; I Lee; H Moustakas; J Muldoon; T M Penning; G Ritacco; N Sadekar; I Schember; T W Schultz; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar; Y Tokura

doi:10.1016/j.fct.2025.115259

Update to RIFM fragrance ingredient safety assessment, 4,8-dimethyl-7-nonen-2-ol, CAS Registry Number 40596-76-7

Food Chem Toxicol. 2025 Jan 18:115259. doi: 10.1016/j.fct.2025.115259. Online ahead of print.

Authors

A M Api¹, A Bartlett¹, D Belsito², D Botelho¹, M Bruze³, A Bryant-Friedrich⁴, G A Burton Jr⁵, M A Cancellieri¹, H Chon¹, M L Dagli⁶, W Dekant⁷, C Deodhar¹, K Farrell¹, A D Fryer⁸, L Jones¹, K Joshi¹, A Lapczynski¹, M Lavelle¹, I Lee¹, H Moustakas¹, J Muldoon¹, T M Penning⁹, G Ritacco¹, N Sadekar¹, I Schember¹, T W Schultz¹⁰, F Siddiqi¹, I G Sipes¹¹, G Sullivan¹², Y Thakkar¹, Y Tokura¹³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 1200 MacArthur Blvd, Suite 306, Mahwah, NJ 07430, USA.
² Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁴ Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI 48202, USA.
⁵ Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI 58109, USA.
⁶ Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
⁷ Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
⁸ Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon 97239 USA.
⁹ Member of Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104-3083, USA.
¹⁰ Member Expert Panel for Fragrance Safety, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996- 4500, USA.
¹¹ Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.
¹² Research Institute for Fragrance Materials, Inc., 1200 MacArthur Blvd, Suite 306, Mahwah, NJ 07430, USA. Electronic address: [email protected].
¹³ Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

PMID: 39832707
DOI: 10.1016/j.fct.2025.115259

No abstract available