What We Know About TMEM175 in Parkinson's Disease

CNS Neurosci Ther. 2025 Jan;31(1):e70195. doi: 10.1111/cns.70195.

Abstract

Background: Lysosome is a highly heterogeneous membranous organelle in eukaryotic cells, which regulates many physiological processes in the cell. Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. At present, it has been confirmed that TMEM175 is related to the pathogenesis of PD, but the relationship between the two remains unclear.

Aims: A thorough comprehension of the structure and function of TMEM175 would greatly contribute to elucidating the achievement of this objective. In this paper, the structure, composition, and function of TMEM175 and its relationship with PD will be reviewed.

Keywords: TMEM175; lysosome; parkinson's disease; proton channel.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channels / metabolism
  • Lysosomes* / metabolism
  • Membrane Proteins / metabolism
  • Parkinson Disease* / metabolism
  • Potassium Channels

Substances

  • TMEM175 protein, human
  • Membrane Proteins
  • Ion Channels
  • Potassium Channels